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(b) Lowes, R

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28 note to investors, William Blair analysts wrote that Applied Therapeutics suspects the CRL was related to the efficacy package as opposed to [chemistry, manufacturing and controls] or safety. Results from the Phase III ACTION-Galactosemia Kids study, unveiled in April 2023, showed that govorestat fell short of its primary efficacy endpoint, a composite of four clinical measures designed to assess various domains of galactosemia symptoms

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IV glutathione bypasses GI degradation and achieves higher bioavailable concentrations, making it potentially more effective for certain clinical goals

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Concurrent mitochondrial dysfunction reduces ATP availability, potentially weakening the Na+-dependent driving force and regulatory phosphorylation processes required for OCTN2 membrane localization [113]

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Efficient production of glutathione in Saccharomyces cerevisiae via a synthetic isozyme system

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