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Either the overproduction of the Fe 2+ that is involved in the formation of lipid hydroperoxides through the Fenton reaction 111 or the inactivation of glutathione peroxidase 4, which is programmed to degrade lipid hydroperoxides, leads to intracellular lipid hydroperoxide accumulation to a lethal level, ultimately triggering ferroptosis 112

The real danger is prolonged exposure over days

Prior to this date, it was not approved for use as the initial therapy for patients with the condition

doi: 10.1007/s13770-024-00668-8 189 PengSSunCLaiCZhangL

Because peptides are rapidly cleaved by proteases, intact BPC-157 rarely persists beyond 812 hours post-dose