A landmark review just published in Frontiers in Toxicology (Karmaus et al., 2026, see comments) systematically compiled replicability data across in vivo guideline studies for the first time
Mills S, Candow DG, Forbes SC, Neary JP, Ormsbee MJ, Antonio J
Developing desirable pigment changes while on synthetic melanocyte stimulating hormone(s) can take weeks to months for results
Their second approach identified four additional cases of death, which were attributed to malignancy related to pancreatic cancer (but without histological documentation) by the adjudication committee (GLP-1 n = 13 and placebo n = 9)
Clinical Effectiveness: SURMOUNT-1 Trial (Tirzepatide 15 mg): Duration: 72 weeks Participants: 2,539 adults with obesity Average Weight Loss: 22.5% of body weight 10 mg Dose: 21.4% weight loss 5 mg Dose: 15.0% weight loss Placebo: 2.4% weight loss 5% Weight Loss: 96% of participants 10% Weight Loss: 89% of participants 15% Weight Loss: 78% of participants 20% Weight Loss: 63% of participants This is the best weight loss result ever achieved with medication in clinical trials
