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The precise regulation of ALS pathogenetic mechanisms is still elusive, despite the abundance of identified mechanisms mediating MN degeneration and death, including neuroinflammation, glutamate excitotoxicity, altered RNA metabolism, mitochondrial dysfunction, impaired cytoskeletal integrity, altered axonal transport dynamics, OS [71, 84, 85]

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NAD + also regulates non-redox NAD + -dependent enzymes such as poly-ADP-ribose-polymerases (PARPs) and sirtuins 519

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