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Limited head-to-head trials directly compare topiramate-plus-GLP-1 combinations against GLP-1 monotherapy at equivalent doses

According to the Zepbound prescribing information, tirzepatide commonly causes nausea (24-29%), diarrhea (18-24%), vomiting (8-11%), constipation (16-17%), and abdominal pain (10-15%), with rates increasing at higher doses

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