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Week 48: This is typically where more people start to notice changes in body composition a leaner look, easier muscle maintenance, or a general sense of improved vitality

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R Met/Met individuals have higher synaptic dopamine and norepinephrine (because COMT clears them more slowly), which improves prefrontal cortex function and working memory but increases susceptibility to stress-related anxiety, pain sensitivity, and catechol estrogen accumulation

[3,4] Both were large randomized placebo-controlled trials, following participants for up to 4 years