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Type 2 diabetes or prediabetes is another strong qualifying condition

Maintaining a good glycemic control is mandatory, as both hyperglycemia and hypoglycemia are associated with enhanced inflammatory profile and acute cardiovascular event

"Without a healthcare professional to manage dose titration and monitor for side effects, people are essentially self-medicating with a powerful treatment

O maior cuidado com esses pacientes a necessidade de ateno com as eventuais comorbidades e o uso contnuo de outras medicaes, a chamada polifarmcia

Re-titrating takes 8 to 20 weeks to reach a therapeutic maintenance dose but reduces the rate of early discontinuation due to adverse effects