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Gulzar et al
2 The chemosensitization effect of QUE in cancer chemotherapeutic The mechanisms of chemotherapeutic drugs are complex and include effects on DNA structure, inhibition of nucleic acid synthesis, DNA replication, and interference with mitotic tubulin ( 2.1 5-Fluorouracil 5-FU is a metabolic inhibitor that interferes with nucleic acid metabolism by inhibiting cancer cells thymidylate synthase (TS) activity, blocking their DNA synthesis, and inhibiting their proliferation
GOx, as an enzyme catalyst which catalyzed the conversion of glucose into H 2 O 2 , can produce starvation effect on tumor cells as well as provide raw materials for Fenton-like reactions
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