In normal female rats, continuous infusion of GHRP has been reported to induce tachyphylaxis after an initial increase in growth velocity, suggesting that continuous infusion of GHRP induces desensitization.27 Repeated administration of hexarelin at 120-min intervals decreased the magnitude of the GH response in healthy adult males.25 In our study, oral administration of MK-677 did not stimulate GH secretion after treatment for 6 weeks, suggesting that the initial GH stimulatory effect of MK-677 was abolished in animals treated with MK-677 for 6 weeks
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