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Over time, this compensatory mechanism can become insufficient, leading to elevated blood glucose and potentially progressing to type 2 diabetes mellitus

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Unlike G6PD in males, G6PD in females is more complicated because of the X-linked recessive hereditary pattern and the random inactivation mechanism of X-chromosomes

In various cancer models, PRODH has been described as a context-dependent tumor suppressor or promoter, depending on the metabolic state and microenvironment of the cell 63