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In the future, in-depth elucidation of the regulatory rules of gut microbiota on tryptophan metabolic shunting and the interaction mechanisms between tryptophan metabolites and core regulatory nodes of ferroptosis, such as host iron homeostasis and GPX4 activity, is not only expected to reveal the regulatory effects of non-cysteine amino acids on ferroptosis, but also provide new theoretical support for the development of precise intervention strategies for OA based on gut microbiota metabolites

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