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We dont necessarily know the long-term impact theyre having on our brains

In humans, GLP-1R expression has been found in atrial and ventricular tissue (45, 46), including cardiomyocytes (22)

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Besides an increased homocysteine export from tissues into plasma that may be regulated by a reduced-homocysteine carrier (Blom, 2000), hyperhomocysteinemia can result from reduced renal function, which may have a central role in plasma homocysteine clearance, and from chronic hepatic insufficiency

It is important to distinguish between back pain that may be coincidental, related to the weight loss process itself, or potentially indicative of more serious complications such as pancreatitisa recognised adverse effect of GLP-1 receptor agonists