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Astrocytic ApoE reprograms neuronal cholesterol metabolism and histone-acetylation-mediated memory

Most cytokines and their receptors are expressed by neurons and glial cells throughout development, and several studies have revealed that cytokines play important roles in neurogenesis, synapse formation, and plasticity, including IL-1, IL-6, TNF-, TGF-1 and IFN 326,327,328,329,330,331 Cytokines activate several signal transduction pathways, including the Janus kinase-signal transducer and activation of transcription (JAK-STAT) and PI3K/AKT/mTOR pathways, which regulate numerous cellular responses

AOD9604 targets fat-rich areas and promotes fat breakdown without disturbing the overall metabolic profile

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Media was changed once every 23 days and supplemented with 1 g ml 1 laminin weekly to promote cell attachment