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Los mecanismos detrs de estos cambios en el peso varan de frmaco a frmaco: los secretagogos y la insulina revierten los efectos catablicos de la diabetes, mientras que las glitazonas aumentan la proliferacin de los adipocitos y causan retencin de fluidos (13)

A.AmirahmadiS.WardC.FabryZ.JohnsonJ

We showed that the antibody Fab fragment (Fab 3F52) blocked the GLP-1 binding site of the ECD directly and thereby acts as a competitive antagonist of native GLP-1

doi: 10.2337/dc09-1348

That is a problem for several reasons: GLP-1 medications carry boxed warnings about thyroid C-cell tumors in rodents and are contraindicated in people with a personal or family history of medullary thyroid carcinoma or MEN2