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In rodents, dual agonism decreases renal TGF- by 40% and preserves nephrin expression, effects recapitulated as lower macroalbuminuria in SURPASS-4 [29]

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Although these agents produce substantial and sustained weight reduction, emerging clinical observations suggest that chronic therapy may be accompanied by changes in lean mass trajectory, reduced protein intake, and micronutrient insufficiency

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Rapid biomimetic remineralization of the demineralized enamel surface using nano-particles of amorphous calcium phosphate guided by chimaeric peptides