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Cold sensitivity likely results from metabolic changes associated with weight loss, including reduced adipose tissue insulation, decreased basal metabolic rate, and adaptive thermogenesis from caloric restriction

Research-grade availability has become limited due to patent enforcement

A 2025 RAND survey on GLP-1 use in the United States found that about half of adults on GLP-1 agonists report experiencing nausea

A combination of experimental and computational studies was conducted and suggested the weaker SeN bond plays a key role in the completion of the catalytic cycle

Alghamdi FA, Alshegifi HA, Alhuthayli RS, et al