step up trial semaglutide 7.2mg achieved 20.7% weight loss in obesity Phase 3 Trial of Semaglutide

Given the known side effects of GLP-1s such as intestinal discomfort and muscle loss, most people have trouble staying on them for more than a year and the weight loss is often reversed once they stop

Clinical studies have shown that GLP-1 Agonist injections can lead to significant weight loss

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doi:10.4158/CS-2019-0472 45Kristensen SL, Rrth R, Jhund PS, et al

Its common for people with PMOS to also have insulin resistance, which can develop into Type 2 diabetes