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Key points: We need to eat in a calorie deficit to lose weight If our baseline diet is rich in ultra-processed foods and we continue to eat this way on semaglutide, we may still consume more calories than we need to lose weight Its essential to eat a diet based on whole foods to support sustainable weight loss 2) Youre in a weight-loss plateau Suppose weve lost some weight on semaglutide, but then we hit a plateau, and we cant budge the scales any more