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Lab Tests Diagnosis and monitoring typically involve serum B12 levels, complete blood count (checking for macrocytic anemia), and sometimes methylmalonic acid or homocysteine levels for confirming functional deficiency

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Chen et al., Complications SCD causes a wide range of complications in various of the body's systems, shown in Figure 2, including the cardiovascular, reproductive, pulmonary, renal, hepatobiliary, and can even cause neurocognitive dysfunction (Kato et al., Figure 2 The clinical hallmark and primary cause of SCD hospitalisations are vaso-occlusive crises (VOCs) (Rees et al., Disease-Modifying Drugs Hydroxyurea Hydroxyurea acts as an inhibitor of ribonucleotide reductase, thereby inactivating enzymes involved in cellular division (Inusa et al., 1976

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