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We discovered a first-in-class inhibitor of the TRF1:TIN2 interaction (compound 40 ) that binds to TRF1 TRFH with a K D of 29 M (95% CI: 2041 M), displaces a TIN2 probe with an IC 50 of 67 M (95% CI: 10120 M), and expels TRF1 from purified shelterin

doi: 10.1038/s41590-020-0699-0 26 JiangD.GuoY.WangT.WangL.YanY.XiaL.et al

No es grasa, es agua en el tejido muscular, y es un efecto esperable, reversible y asociado precisamente a que el suplemento est funcionando

While this is an established technique 84,85 , this approach is less physiologically relevant than orally administered glucose, as it bypasses incretin hormone signaling that could significantly impact insulin secretion and glucose homeostasis 86

[DOI] [PMC free article] [PubMed] [Google Scholar] 43.Exploring the aspect of psychosomatics in hypothyroidism: the WOMED model of body-mind interactions based on musculoskeletal changes, psychological stressors, and low levels of magnesium