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Consistent with the nuclear action of Lani, most proteins downregulated by GLP-1GIPLani (cluster 1) were associated with nuclear processes such as RNA processing, neurotransmitter receptor internalization and chromosome organization, whereas proteins upregulated by GLP-1GIPLani were mainly linked to neurotransmitter receptor internalization (Fig

And the larger clinical trial evidence (STEP 9 in knee osteoarthritis patients, the SLIM LIVER study) supports the view that the disproportionately larger loss of fat relative to LBM results in improved mobility and physical function, even when absolute LBM declines