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Abbreviations Akt, PKB: Protein kinase B AP-1: Activator protein 1 IP3R: Inositol 1,4,5-trisphosphate receptor Mdm2: Mouse double minute 2 NFAT C 4: Nuclear factor of activated T cell 4 PDK1: Phosphoinositide-dependent kinase-1 PH domain: Pleckstrin homology domain RH domain: Regulator of G protein signaling homology domain SDS-PAGE: Sodium dodecyl sulfate polyacrylamide gel electrophoresis USP33: Ubiquitin carboxyl-terminal hydrolase 33 References Hausdorff WP, Caron MG, Lefkowitz RJ