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Functional analysis of genetic variation in catechol-O-methyltransferase (Comt): Effects on mRNA, protein, and enzyme activity in postmortem human brain

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Vitamin B6, in the form of pyridoxal-5'-phosphate, is the cofactor for 5 enzymes in the -glutamyl cycle and trans-sulphuration pathway: cystathionine -synthase, cystathione -lyase, cytoplasmic and mitochondrial serine hydroxymethyltransferase and glycine decarboxylase in the mitochondria