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The slope of the cumulative incidence curve for the semaglutide or tirzepatide group was consistently larger than that for the comparison group, indicating the potential sustained association of semaglutide or tirzepatide with risk of NAION and other optic nerve disorders
Multivariate Cox Regression analysis was performed using the high-dimensional propensity score to obtain adjusted Hazard Ratio (HR) estimates
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In a controlled study measuring ad libitum eating (meaning participants could eat as much as they wanted), semaglutide reduced total energy intake by 24% across all meals throughout the day
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