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Histochem Cell Biol 158 , 213227 (2022)

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288,289 In one study, 44% of untreated patients but 38%, 28% and 9% of patients treated with CRS, CBT-I, and CBT-I + CRS, respectively, experienced clinically significant worsening of depressive symptoms during a 1-year follow-up period

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19 Studies show that after TPE treatment, natural killer cells and CD8 T cells increase, reducing inflammatory macrophages and enhancing adaptive immunity