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These results provide an important benchmark when comparing the magnitude of benefit seen with GLP-1 RAs and dual/triple incretin agonists, which in phase 2 and 3 studies have shown higher rates of MASH resolution but with less consistent antifibrotic effects

Consistency in following a strict diet is key to achieving and maintaining weight loss

Starting even lower and escalating even more gradually should theoretically produce even fewer symptoms, at the cost of a longer time to reach therapeutic levels

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