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Metabolic syndrome in the Pressioni Arteriose Monitorate E Loro Associazioni (PAMELA) study: daily life blood pressure, cardiac damage, and prognosis

Research has shown that metabolic reprogramming in tumors is involved in the activation and differentiation of hepatic stellate cells (HSCs), such as acidification of the microenvironment inducing HSC activation and differentiation into myofibroblasts in a P-Erk1/2-dependent manner ( Compared with quiescent HSC (qHSC), activated HSC (aHSC) exhibit higher rates of glucose utilization, transport capacity, and glycolytic activity ( Rapid proliferation of liver cancer cells can deplete nutrients in the microenvironment, leading to sustained nutrient deprivation and decreased oxygen levels

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Screening efforts to explore the pharmacopeia for antimicrobial compounds also identified auranofin and ebselen for antimicrobial properties that appear to also target TrxR (Figure 2)

PMID 23861405