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Foralumab, the only fully human anti-CD3 monoclonal antibody (mAb) currently in clinical development, binds to the T cell receptor and dampens inflammation by modulating T cell function, thereby suppressing effector features in multiple immune cell subsets

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doi: 10.3389/fendo.2025.1629488 Received 15 June 2025 Accepted 14 August 2025 Published 10 September 2025 Volume 16 - 2025 Edited by Federico Bertuzzi, Niguarda Ca Granda Hospital, Italy Reviewed by Pratikeswar Panda, Siksha O Anusandhan University, India Basilio Pintaudi, ASST Grande Ospedale Metropolitano Niguarda, Italy Updates Copyright 2025 Castorani, Chiarle, Savastio, Pozzi, Partenope, Pignatiello, Dimarakis, Demichelis, Medina and Rabbone