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Getting this calculation right is critical for safety and efficacy

4 Discussion At present, the therapeutic options available for pediatric patients with diabetes are somewhat limited, only insulin, metformin, daily liraglutide and once-weekly exenatide extended release are applied in clinical practice

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large-scale randomised controlled trials specifically designed to assess cognitive outcomes are still ongoing Uncertainty about mechanisms : It remains unclear whether any cognitive effects result from direct brain effects, improved metabolic control, or other factors Population specificity : Most research has focused on individuals with type 2 diabetes