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A systematic comparison of the alkylphenol 4- tert -octylphenol, commonly used in paints, pesticides, herbicides, detergents and plastics, with the synthetic estrogen DES, found equal magnitude effects on preventing the ability to exhibit an LH surge and induce ovulation in rats (240)
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doi: 10.1084/jem.20061308 82 HagensGRoulinKHotzRSauratJHHellmanUSiegenthalerG
Therefore, a key question is whether certain individuals have an inflection point for clinically important paracetamol toxicity at a dose within or close to the recommended therapeutic dose
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