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In the case of TB, there is a very strong genetic basis of susceptibility to this bacterium, with resistance developing among the indigenous north American population after European colonization, owing to the high initial mortality and therefore rapid selection against susceptibility genes (Abel et al., 2018)

Beyond its role as a shield, it is also vital for the detoxification process in the liver and supports the immune system's ability to repair damaged tissues

Its second-generation counterpart, KV-49g, stands out as the most effective and selective AKR1C3 inhibitor known, overcoming resistance to anti-cancer agents apalutamide and darolutamide (Verma et al., 2019

The usual care group received a standard physician-practice recommendation that patients notify family members about their diagnosis

doi: 10.3389/fgene.2022.975381 45 LiHWuCChangWZhongLGaoWZengMet al