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doi: 10.37871/jbres2092 256

109,110 GRs are expressesd at higher levels and particularly concentrated in the pituitary and hypothalamus, as well as a variety of regions of the limbic system (including the amygdala, hippocampus, and PFC), which are important for cognitive and psychological functions

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Retatrutide's glucagon receptor agonism can transiently raise blood glucose, whilst its GLP-1 activity promotes insulin secretion and lowers blood glucose