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In the presence of GSH, the chemotherapeutic drug chlorambucil (CBL) behaves as an efficient substrate for human GSTA1-1 (hGSTA1-1)

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Reduced glutathione operates as the active, functional antioxidant form, making it particularly effective in neutralizing free radicals and supporting essential cellular processes advantages not matched by other variants such as oxidized glutathione

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176 In addition to non-selective autophagy induced under starvation conditions, researchers have found that cells can also target the degradation of damaged or redundant organelles, protein aggregates, and invading pathogens for selective autophagy