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Along this line, eHSP90 has been recognized as a promising marker of tumor malignancy, and it predominantly contributes to the higher sensitivity of tumor cells to HSP90i and the tumor retention effect by the binding to pharmaceutical agents targeting HSP90 [20,21,22,23]

Cancer Chemother Pharmacol 1996

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Effect of metformin on lipid profile of type II diabetes

Indeed, a mouse model of impaired (gene knockout) BCAA catabolism showed that accumulation of BCAAs or their intermediate metabolites (branched-chain -keto acids, BCKAs) in the heart suppressed glucose metabolism by decreasing glucose uptake and mitochondrial pyruvate utilization, a key step of glucose oxidation, and promoted fatty acid oxidation 72,74,75