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Evidence has determined that elevated oxidative damage to proteins, lipids, and nucleic acids is a distinctive characteristic of the motor cortex and spinal cord of ALS patients, together with high levels of KEAP1 and a decrease in the NRF2-target genes and related enzymes

-LA, a naturally occurring dithiol with antioxidant and anti-inflammatory function, can decrease the interaction between Nrf2 and Keap1, inhibit the pro-inflammatory cytokine IL-8 production and minimize the infection via the Nrf2/HO-1 pathway in the AGS cells (161)

Cytokines are small proteins that play an important role in immune responses, such as regulating inflammation and blood cell production

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Gollwitzer H, Diehl P, von Korff A, Rahlfs VW, Gerdesmeyer L