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The American Gastroenterological Association recommends starting with conservative dietary and lifestyle measures before progressing to pharmacological interventions

The microbiome approach: intriguingly, some are attempting to engineer gut bacteria to secrete GLP-1 analogues (or fragments) in situ, to provide continuous low-level GLP-1 stimulation

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PMID: 41583068 J Transl MedTruncated APC impairs innate immune response by targeting MAVS on mitochondria in colorectal cancer