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When semaglutide's popularity exploded following FDA approval for weight management in 2021, so too did a wave of calls to poison control centers

Blood levels of CRP above 3 mg/L are suggested to be predictive of adverse cardiovascular outcome one year later 48

One study found that since the IRAs introduction, aggregate small-molecule investment by pharmaceutical companies valued under $2 billion has declined by 68%

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Robust randomized trials and meta-analyses consistently show significant reductions in major adverse cardiovascular events, meaningful weight loss, improved blood pressure control, and favorable renal outcomes, including slower decline in estimated glomerular filtration rate and reduced albuminuria