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longum R0175 significantly reduced Hospital Anxiety and Depression Scale (HADS) global scores and Hopkins Symptom Checklist (HSCL-90) global severity indices in healthy volunteers, alleviating somatization, depression, and anger-hostility symptoms (Messaoudi et al., 2011)

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Dose Selection: The trials evaluated doses ranging from 0.25 mg to 54 mg, with higher doses showing increased gastrointestinal effects

Semaglutide does not directly cause gastritis, but by slowing stomach emptying, it can intensify nausea and bloating in patients with active inflammation

PYCR1, frequently found in complex with kindlin-2, also plays a critical role in mitochondrial proline biosynthesis and fibroblast activation