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Human evidence for cognitive benefits with GLP-1 receptor agonists remains mixed and inconclusive, and definitive evidence for tirzepatide specifically is not yet available

GLP-1 (glucagon-like peptide-1) receptor agonists are a class of medications that were initially developed to manage type 2 diabetes

A growing body of evidence points to GLP-1 receptors distributed throughout the brain in regions governing reward processing, craving, and impulse control

In March 2024, the U.S