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In hepatocellular carcinoma, PRMT1 catalyzes the methylation of PHGDH at residue R236 to enhance its enzymatic activity ( The tumor classification based on SSP activation patterns reveals that the conserved mechanisms of SSP, including redox homeostasis maintenance, one-carbon metabolism and drug resistance regulation, can serve as universal targets for pan-cancer therapeutic interventions

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Shorter telomeres are associated with decreased lifespan

Hayden MR, Grant DG, Aroor AR, DeMarco VG