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This study uncovers a functional link between altered iSPN BDNF-TrkB signalling, glutathioneascorbate metabolism and hyperdopaminergic state, underscoring the vital role of GSTO2 in maintaining dopamine balance

Early studies focused purely on blood sugar control, but researchers began noticing improvements in cardiovascular health, weight management, and overall wellbeing that suggested something more significant was happening at the cellular level

Through transmethylation, glycine and sarcosine are interconvertible

5 and 6 (5a-e & 6 a-e respectively)

Drugs in development: Retatrutide is a triple agonist that targets GLP-1, GIP, and glucagon receptors