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GLP-1RA has been shown to exhibit anti-atherogenic and anti-inflammatory effects, while SGLT-2i modulates vascular hemodynamics

Other GLP-1s have not listed dysesthesia as an adverse effect

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Mechanistic studies demonstrated that the TM6SF2 E167K variant increased the interaction between TM6SF2 and PNPLA3, and impaired PNPLA3-mediated transfer of polyunsaturated fatty acids (PUFAs) from TG to PC