[Updated 2024 Dec 15]
Appetite and weight changes present another consideration
We had this great heyday 30 years ago of small molecule drugs that you could manufacture relatively easily by mixing chemicals, but after those patents expired, and these could be manufactured by other companies as generics and sold to everyone for cheap, we really haven't discovered something like that since
Untreated or under-treated hypothyroidism affects energy expenditure and fluid balance, and its symptoms fatigue, cold intolerance, constipation overlap with common GLP-1 adverse reactions, which makes attribution difficult when both are changing simultaneously
RSL3 increased oxidized membrane lipid levels, as measured by confocal and flow cytometry using the dye C11-BODIPY in CRC DTP cells compared to the parental cells, supporting the notion of increased susceptibility of CRC persister cells to ferroptosis after 5-FU or AZ628 treatment ( Figures 3G, H )