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While they usually improve with time, about 1 in 10 people ultimately stop taking semaglutide due to side effects

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Diabetes Ther (2019) 10:519

The study found that patients taking Mounjaro and oral contraceptives together resulted in a 20% decrease in overall exposure to oral contraceptives

This means semaglutide users often add more water (2-3mL) to keep lower doses measurable, while retatrutide users at higher doses may prefer less water (1mL) to keep injection volumes manageable