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Are Oxidative Stress Mechanisms the Common Denominator in the Progression from Hepatic Steatosis towards Non-alcoholic Steatohepatitis (NASH)

In a phase 2 clinical trial involving 30 MASH patients with advanced fibrosis (NCT02421094), GR-MD-02 had no significant effect on non-invasive biomarkers of liver inflammation or fibrosis after 16 weeks, as measured by magnetic resonance elastography and shear-wave ultrasonic elastography, since histopathology monitoring was not planned for this study

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Efficacy of zinc treatment against iron-induced toxicity in rat hepatoma cell line H4-II-E-C3