GLP1 GLP-1-1 GLP1GLP-12 GLP1 GLP-1 GLP-1 BMIkg (m) 2 25 GLP-1 GLP-1 GLP-1GLP-1 15 61012 12 120mL303mg1117mg 1,6501,100 QA 3mg7mg 3mg3mg47mg14mg 2 GLP-1 30 3030 2 GLP-1 2 GLP-1FDA28
From a biology standpoint, its plausible
While oral administration is less invasive than injection, a recent study indicated no difference in preference between oral semaglutide and dulaglutide [132]
Considering the potential of secondary bile acids to increase L-cells and GLP-1 secretion by TGR5, TGR5 agonists are promising drug candidates for increasing L-cells and GLP-1 secretion [180, 181]
Yang Y, Chen L, Zhang Y, Fu W, Liu D, Jiang T (2025) Research on the effects of GLP-1 receptor agonists in treating cognitive dysfunction and gait disorders in elderly patients with diabetes