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As mitochondria are sensitive to stress mediators, including cortisol in humans and corticosterone in mice, and mitochondrial respiration is a primary source of cellular energy, it is postulated that allostasis involves metabolic and mitochondrial mechanisms 37,39,40,41,42,43

Generation of hMSC cells in the Ryan lab was supported by 19/FFP/6446Research Ireland Frontiers for the future award

The discovery of epitalon, a tetrapeptide with the amino acid sequence Ala-Glu-Asp-Gly, was a direct result of efforts to develop safe and effective methods for offsetting adverse effects of aging

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