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Correcting B12 changes your metabolism and nervous-system signalling, and that adjustment itself can feel like tiredness, lightheadedness or a vague off feeling before things settle

J Transl Med 21(1):425 Mu Q et al (2021) The role of iron homeostasis in remodeling immune function and regulating inflammatory disease

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In June 2025 , a meta-analysis of brain imaging studies published in Psychopharmacology reveals that individuals with major depressive disorder exhibit significantly lower glutathione levels in the occipital cortex compared to healthy controls