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Studies show FOXO4-DRI treatment reduces senescent cell markers including p16, p21, and senescence-associated -galactosidase activity by over 50% in expanded human chondrocytes at population doubling level 9 (PDL9), the stage typically used for clinical implantation

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Skipping doses, changing injection times randomly, or taking weeklong breaks in the middle of a cycle disrupts the hormonal patterns these compounds are trying to establish