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however, zinc therapy had no effect on tinnitus loudness or intensity and did not improve hearing

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The poor bioavailability of exogenous SODs has been criticized

Together, these results suggested to us the possibility that NAC-induced roGFP2 oxidation is caused by sulfane sulfur (S 0 ) species created inside mitochondria, based on the following consideration (summarized in Figure 1E): It is known that H 2 S is very efficiently oxidized by sulfide:quinone oxidoreductase (SQR) to yield hydropersulfides inside the mitochondrial matrix (Libiad et al., 2014)

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